Anti-cancerous Effect of Mebendazole

  • Post comments:16 Comments
📄 4 mins.

Introduction

Mebendazole (MZ) (methyl 5-benzoyl-2-benzimidazole-carbamate) is a broad-spectrum anthelmintic (antiworm) drug. It is used to inhibit the growth and multiplication of newly hatched insects in your body. It promotes the depolymerization of tubulin and destroys the function of microtubules in insects. Benzimidazole has two derivatives MZ and albendazole. MZ has anticancer activity. It causes mitotic arrest in cancerous cells that leads to cell death. It is very effective against lung cancer.

Non-small cell lung cancer

Lung cancer is one of the leading causes of death all over the world. Non-small cell lung cancer (NSCLC) is very common kind (85%) of lung cancer in smokers and non-smokers. It is more common in females than in males. NSCLCs have a very poor prognosis and such patients are less sensitive to chemotherapy as compared to small cell carcinoma.

Mechanism of Action

Scientific studies have shown that MZ prevents the normal spindle formation in NSCLC by inhibiting the polymerization of tubulin. This abnormal spindle formation causes mitotic arrest at prometaphase of cell division and ultimately leads to cell death. Mebendazole also induces phosphorylation and produces changes in the expression of cell cycle regulatory proteins that are also associated with the mitotic arrest. After the mitotic arrest in cancer cells, Mebendazole initiates apoptosis (cell death) in NSCLC cells. However, this mechanism is not entirely understood. Chemotherapeutic agent paclitaxel acts on these cancerous cells just like MZ by more than one pathway, induces the destruction of mitochondria and causes apoptosis. It causes phosphorylation of certain proteins such as Bcl-xl or Bcl-2 and damages the microtubules of the cell. Studies claimed that this phosphorylated protein Bcl-xl or Bcl-2 causes increased Bax level. This condition favors cell apoptosis.

In vitro MZ treatment

In vitro treatment, MZ prevents the growth of NSCLC cell lines. Only 0.1 µM dose of MZ can suppress the proliferation of cells significantly. A dose of 10 µM suppresses the 75% of cell lines. The standard dose is 0.5 µM for in vitro experiments. In NSCLC cell lines, A549 cells are the least sensitive cells to MZ and H460 cells are the most sensitive cells to Mebendazole. It causes condensation and destruction of the nuclear membrane that leads to mitotic arrest of dividing cancer cells. Researches show that when in vitro apoptosis was induced by MZ Treatment, after 24 hours, sub-diploid cells increased significantly. The level of cells increases with the duration of treatment. It suggests that Mebendazole promotes cell death after the mitotic arrest. MZ induce mitochondria to secrete of cytochrome c to the cytosol of the cell.

Spindle Formation

Proper spindle formation is essential for the normal division of cells. Mebendazole treatment induces abnormal spindle formation in tumor cells. When such cells are treated with Mebendazole, paclitaxel (a chemotherapeutic drug), nocodazole (antineoplastic agent) or DMSO (dietary supplement), they target tubulin polymerization and its status varies with different chemical agents.

In Vivo Tumor Suppression

In scientific research, cells of mice were treated in vivo by Mebendazole with varying doses, it was found that cells receiving 1-mg MZ dose, showed growth inhibition effect remarkably. Numerous experiments showed that MZ treatment is more effective than other chemotherapeutic agents in suppressing cell growth.

Effect of MZ on s.c. Tumor Growth

The anti-cancerous effects of MZ were experimented on H460 xenografts in mice. When tumor cells attained a diameter of 5 mm, a dose of 1mg was given through the oral route. After a treatment period of 7 days, tumor cells showed significant suppression and apoptosis. The following figure shows the remarkable effectiveness of MZ treatment on the tumor cells.   Vitamins + fenbendazole Scientific studies claim that a combination of vitamins and Fenbendazole is effective in suppressing human lymphoma cells. But when we treat the tumor with only fenbendazole, it has no inhibitory effects on tumor cells. Vitamins D, K, A, B, E are supplemented. Vitamins A and E possess antioxidant properties, so they are effective against tumor cells. They inhibit the nuclear transcription factor.

Conclusion

Mebendazole is a famous antiparasitic drug and it has significant activity in microtubule and fibroblast inhibition and suppresses the tumor cells remarkably. No side effects have been reported so far. But when MZ is used to treat alveolar echinococcosis (a parasitic disorder) for the long term, it shows a little bit of tolerable toxicity. But when these cancerous cells are treated with other anthelmintic agents like albendazole, neutropenia is reported. MZ is a useful chemotherapeutic agent and can be used in lung cancer therapy. But when MZ is compared with other chemotherapeutic agents like nocodazole, it is less efficient in depolymerization of tubulin and inducing abnormal spindle formation and in cancerous cells.

This Post Has 16 Comments

  1. Steven

    Fenbendazole tablets are available from Amazon. Cost is about 60 cents for 222mg tablet. Enter “fenbendazole 222mg” into Amazon

  2. Zoe

    It’s a shame you don’t have a donate button! I’d definitely donate to this fantastic blog! I suppose for now i’ll settle for book-marking and adding your RSS feed to my Google account. I look forward to new updates and will share this site with my Facebook group. Chat soon!

  3. Tammy

    I have NSCLC, how can I get a RX for Mebendazole?

    Does meben or fenben cross blood brain barrier?

    1. fenbendazole

      Hello Tammy,
      Both mebendazole and fenbendazole are antiparasitic drugs primarily used to treat worm infections. Their ability to cross the blood-brain barrier (BBB) is a critical factor when considering their potential use in treating central nervous system (CNS) diseases, including brain tumors.
      There is some evidence that mebendazole can penetrate the BBB and reach the brain, making it a potential candidate for treating brain-related diseases. In contrast, there is some evidence and research on fenbendazole’s ability to cross the BBB, however, its efficacy in treating CNS diseases is not well established.
      Regarding your question about prescribing mebendazole: Your healthcare professional will likely not agree to prescribe mebendazole for lung cancer. You might consider searching and purchasing it online.
      In conclusion, mebendazole and fenbendazole are both likely to be helpful in your case.

  4. Lauren Chun

    I started taking febendazole yesterday, I’m having a constant headache and could not sleep. Is that normal? Has anyone else experienced the same thing? I used to take mebendazole for over a year and now I switched.

  5. Julius

    Can Milk thistle replace tudca? I’m taking milk thistle with mebendazole, I want to add fenben and wonder if I can stay on milk thistle or need to add tudca?

    1. Fenbendazole.org

      You can use milk thistle as long as you don’t have an estrogen or HER2 driven cancer.

      1. Lou B

        How can I find out if my cancer is estrogen or HER2 driven ? I have been unable to upon researching.

        Thank You

        1. fenbendazole

          Hello Lou B,
          To determine whether your cancer is estrogen receptor (ER+) or human epidermal growth factor receptor 2 (HER2+) positive, your healthcare provider must perform specific tests on a sample of cancer tissue. Talk to your oncologist about appropriate tests to identify these factors and tailor treatment accordingly.

  6. Charlie Castro

    Is Fenbendazole or mebendazole better for Glioblastoma??

  7. Mary B.

    Where can I purchase mebendazole?

  8. Louise

    Thank you so much for putting this info out there. Seriously amazing

  9. Kilwanna Williams

    Can I purchase this drug? My uncle has stage 2 cancer. Will my Provider/Presribe this for me?
    Thanks Kilwanna

    1. Fenbendazole.org

      Dear Kilwanna,
      thank you for your question. Depending on where you live, you can buy mebendazole without a prescription or with a prescription from your doctor. Most doctors won’t give you mebendazole if you don’t have parasites, so you can try purchasing fenbendazole instead if you can’t get mebendazole. Fenbendazole is available as a veterinary medicine (Panacur or Safeguard). You can also check the “suppliers” section of our page for a more complete list of places where you can get some fenbendazole. Hope this helps

  10. Donte Slim

    I have read so many content about this however this post is really nice, keep
    it up.

    1. Fenbendazole.org

      Dear Donte,

      Thank you for your appreciation! We are happy to provide information that helps.

      Best regards,

Leave a Reply